I love python and Django is probably the best Web application framework I have ever worked with, but it isn't without its issues. It has an absolutely great built-in, auto-generated admin interface for directly modifying database objects. It is incredibly convenient and takes care of most common Web application administration needs for the vast majority of applications. That being said, if it doesn't work for your application it can be painful to shim extended admin interfaces into it.
For example it doesn't really fit with Formunculous or File Manager than it is pretty much the exact opposite of convenient. I have wrestled with integrating other application's admin interfaces into the Django admin with out much success. The look and feel is easy thanks to template extensions, but just creating a simple link to your extended admin views is just not there, and there isn't really a recommended way to do it.
